Post by drizsak on Apr 30, 2014 14:35:59 GMT -5
Pediatric pneumonia may be effectively treated with twice-daily amoxicillin
In a randomized, placebo-controlled study of 820 pediatric patients with mild pediatric pneumonia, researchers found that treatment with oral amoxicillin (50 mg/kg/day) twice daily was as effective as amoxicillin given three times a day. Treatment failure occurred in 23% of the twice-daily group and 22.8% of the thrice-daily group in the intention-to-treat analysis, and in 21.3% and 20.1% of these groups, respectively, in the per-protocol analysis. Among the 277 patients with radiologically confirmed pneumonia, treatment failure occurred in 18.8% of patients in both groups.
References
Douglas D. Twice-Daily Amoxicillin Effective in Children With Pneumonia. Medscape Medical News. Available at www.medscape.com/viewarticle/823469. Accessed April 22, 2014.
Vilas-Boas AL, Fontoura MS, Xavier-Souza G, Araújo-Neto CA, Andrade SC, Brim RV, et al. Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial. J Antimicrob Chemother. Mar 19 2014;[Medline]
In a randomized, placebo-controlled study of 820 pediatric patients with mild pediatric pneumonia, researchers found that treatment with oral amoxicillin (50 mg/kg/day) twice daily was as effective as amoxicillin given three times a day. Treatment failure occurred in 23% of the twice-daily group and 22.8% of the thrice-daily group in the intention-to-treat analysis, and in 21.3% and 20.1% of these groups, respectively, in the per-protocol analysis. Among the 277 patients with radiologically confirmed pneumonia, treatment failure occurred in 18.8% of patients in both groups.
References
Douglas D. Twice-Daily Amoxicillin Effective in Children With Pneumonia. Medscape Medical News. Available at www.medscape.com/viewarticle/823469. Accessed April 22, 2014.
Vilas-Boas AL, Fontoura MS, Xavier-Souza G, Araújo-Neto CA, Andrade SC, Brim RV, et al. Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial. J Antimicrob Chemother. Mar 19 2014;[Medline]
